About Us

Committed to speeding innovation for science-driven organizations, from product ideation through commercialization.

Events

Visit us at the 9th Annual Proteins & Antibodies Congress

Conference Website

Event Date

18-19 April, 2016

Event Location

London, UK

Hear Us Present

Monday, 18 April @ 15.50 - 16.20

Dr. Guy Georges, Senior Principal Scientist, Roche, will be presenting on our behalf 'Antibody Modeling and Humanization: Towards Rational Engineering'.

Abstract

MoFvAB (Modeling of the Fv Antibody) is automatically producing models of high quality at a very low computational cost. The template search focuses on structurally relevant portions, e.g. CDR3H split in ascending and descending portion from the loop peak, and an accurate prediction of the relative VH-VL orientation ensure the model quality. Finally, a technology based on neighborhood search is used to predict the position of side chains; this represents a fantastic add-on on the classical homology modeling (sequence-based) approach.  A benchmark analysis reveals that our modeling tool systematically better performs than all other published ones. The VH-VL orientation prediction is also used to predict the CDR grafting success during humanization. Quantitative correlations between VH-VL orientation and affinity to antigen will be presented.

Vist Us on Booth #12

Come and visit us on the booth where our experts will be showcasing:

BIOVIA Biologics Solutions - An innovative Biologics suite of process experiences that supports the discovery, developement and manufacturing of biotherapeutics

We look forward to seeing you in London!

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