Discovery Studio 2.5 - Update 2

This update is for Discovery Studio Client released with Discovery Studio 2.5 and includes new enhancements and corrections and enhancements from update 1. For more details, see the following:

Installation

Windows

Linux

  • Download DSC255Setup.tgz. Note that some broswers such as Internet Explorer may download this file with an extension of .gz.
  • Execute the following commands to extract the contents and begin installation:

    tar -xzvf DSC255Setup.tgz (or .gz)
    DSC255Setup.bin

Update 2 (version 2.5.5) - Details

This update includes enhancements and corrections to Discovery Studio 2.5.

  • Discovery Studio has been upgraded to work with the 64 bit version of the Pipeline Pilot 7.5 server. This simplifies the installation process, as you no longer need to maintain both 32 and 64 bit versions, and helps you to improve performance of processor heavy calculations by allowing you to run them on 64 bit servers.
  • MODELER is upgraded to version 9v7, and includes native 64 bit version of the package. In addition, the new version complies with the latest PDB format for DNA/RNA, ligands, and ions (now reads and writes metal ions correctly).
  • CHARMm has been upgraded to version 35b1, and includes a native 64 bit version of the package.
  • New protocols are available: Filter by Property and RCSB Structure Search in General Purpose and
    Create 3D QSAR Model in QSAR.
  • The Dock Ligands (GOLD) protocol has been modified to support version 4.1 of GOLD.
  • New Discovery Guides have been added: Dock Ligands and Sketch and Align Molecules.
  • A new tool panel has been added: Superimpose Proteins.
  • New tools and enhancements have been made for Analyze Binding Site, Analyze Protein Conservation Pattern, Build and Edit Nucleic Acid, and Build and Edit Protein tool panels.
  • Tooltips are enhanced with improved information and links to detailed help.
  • New options and enhancements are available in the Molecule Window and Sequence Window.
  • Scripting includes new methods for accessing plots and dendrogram views, creation of pi-interaction and rotatable bond monitors, and saving images from the Graphics View.

Additional enhancements and bug fixes have been made for details, see "What's new in Discovery Studio 2.5.5" (available from the readme on the distribution before installing, or the product help after installation).

Update 1 (version 2.5.1) - Details

  • .bsml files with missing residue attribute data can now be loaded. Missing residue attributes are replaced by default values.
  • Various enhancements have been made to the Undo feature.
  • Improved Data Table View performance when handling large data sets.
  • Edit | Invert Selection no longer ignores objects that are under hidden molecules.
  • .dsv files now preserve zoom level, translation, and rotation view.
  • Improved the stability of .dsv files.
  • Full screen view now works correctly on Linux.
  • You can now copy and paste molecules from other applications that support MDL Mol/SD clipboard format (e.g., MDL Draw and Accord Draw).
  • Stability improvements have been made for updating preferences.
  • When inserting or dragging and dropping multiple files, all the files are now correctly processed, and Undo can be performed.
  • The Hardware Stereo now works correctly for the following configuration: Linux RedHat 4 Update 4 with an ATI FireGL V7600 card and driver version 8.583.
  • Improvements have been made for typing modified nucleic acid templates.
  • The output from a Calculate Binding Energy protocol run with the receptor flexibility option now opens correctly.
  • Inserting a non-standard AA via scripting now works.
  • Using scripting to add user defined secondary structure to a sequence is now possible.
  • Import/Export of scripts between Windows/Linux platforms is now possible.
  • Opening a .mol2 file containing multiple molecules through scripting now works correctly. This also corrects a related issue in the DS Molecule Reader.
  • Fixed a rare case where molecular properties were occasionally not stored in .dsv files.
  • Fixed a rare issue that ocurred when exporting .sd files from a window containing invisible molecules loaded from a .dsv file.