“We at Addex had a unique target of therapeutic interest but only a small series of congeneric molecules address this difficult problem. We contracted with Accelrys' Contract Research Services team to help ups address this difficult problem. Accelrys had a scientist, with broad industry experience, pursuing our problem using their software immediately after our service agreement was signed. Over the period of two months their scientist developed, implemented and executed an intrinsic scientific approach to our problem. We were kept abreast of his progress through regular phone meetings. Accelrys used their complex consensus search algorithm to look for molecules that would be active, lead-like and possess minimal ADME issues. At the end of the project, we tested three dozen compounds and found two that were active. One was 1.2 mM and the other was 350 nM against the target. As a result of our engagement with Accelrys, we were able to move forward with viable compounds for our novel target.”
Jean-Philippe Rocher, Head of Core Chemistry,
Addex Pharmaceuticals
Work performed by William Shirley, Contract Research Services, Accelrys.
"The use of the Accelrys’s Contract Research Service team provided us the expected benefit of avoiding months of intensive laboratory screening. The modeling work provided by Accelrys also helped us to define and focus our future experiments along the most productive path for commercial and technical success. Furthermore, insights were also gained into additional technical paths that would meet our goals that were not obvious or planned for in our initial scope.” (Work performed by: Amity Andersen and Lalitha Subramanian, Contract Research Services, Accelrys)
Roger Avakian, CTO, & David Jarus, R&D Manager, PolyOne
“From the earliest discussions, throughout the completion of our project, Accelrys’ staff has actively and professionally helped us meet our research needs. The Battery Technology Center of BAE Systems was able to utilize state-of-the-art software and expertise through Contract Research Services at Accelrys, saving our company both time and money.” (Work performed by: Amity Andersen and Lalitha Subramanian, Contract Research Services, Accelrys)
BAE Systems
“Our experience with the Computational Scientist Resource program has been very positive. We are now accomplishing more modeling with less effort by developing more advanced techniques. As a result, we are achieving better designs and faster idea generation with chemists and more quickly implementing these ideas. ”
Jeff Zablocki (Senior Director, Head of Chemistry, CV Therapeutics) and s Hugh Genin (Scientist on-site, Contract Research Services, Accelrys)
Other Languages
